*These documents have been updated to un-link protocols from the Oncofertility Consortium.  Please use as a guideline when submitting amendments to your IRB or starting a new protocol*

Section 1. Oncofertility Guidelines (including Confidentiality Agreements)

PDF icon 01a. Oncofertility Consortium Guidelines

Section 2. Establish your Team; Brand Your Center

PDF icon 02a. Establishing Your Team

PDF icon 02b. Branding Your Center (10/2017)

Additional Branding Resources

Section 3. Review the Equipment and Supplies List

PDF icon 03b. Setting Up Your Programmable Freezer

Section 4. FDA Registration

PDF icon 04. Updating or Establishing Your FDA Registration

Section 5. Memorial Blood Center: Infectious Disease Testing

IMPORTANT NOTE: If ovarian tissue is removed vaginally, it changes the infectious disease testing that must be done.  Tissue that comes into contact with the genitourinary tract necessitates GC and Chlamydia testing.

PDF icon 05a. Testing for Infectious Diseases (10/2017)

PDF icon 05b. Sample Blood Drawing Request

Section 6. Reprotech: Accounts, Logistics, and Donor Eligibility 

PDF icon 06a. ReproTech: Accounts, Logistics and Donor Eligibility Determination (10/2017)

06b. Summary of Records (see below documents)

IMPORTANT NOTE: It is up to each site to determine if patients will be tested as anonymous donors.  If your site is doing donor eligibility in case the patients must use a gestational surrogate or other methods to establish pregnancy, donor eligibility requirements must be followed to treat the cryopreserved ovarian tissue as though it came from anonymous donor of leukocyte tissue and must undergo donor eligibility determination prior to shipping tissue to ReproTech. 

Microsoft Office document icon 06b1. HCTP SOR DED Not Performed.doc

Microsoft Office document icon 06b2. HCTP SOR DED Was Performed.doc

Microsoft Office document icon 06b3. HCTP SOR DED Subsequently Performed.doc

Section 7. Sage/Origio: Establishing an Account and Ordering Media 

IMPORTANT NOTE: As of October 16, 2017 sites are responsible for purchasing slow-freeze media themselves (outlined in document below). 

PDF icon 07a. Establishing an Account and Ordering Media from Sage (10/2017)

Section 8. Clinical Tips: Patient Flow, Tissue Transport, Surgical Removal and Pathology

This section describes typical patient flow, a discussion of how to transport the ovary from the operating room, tips for surgical removal and strategies for providing an adequate sample for examination by pathology.

PDF icon 08a. Typical Ovarian Tissue Cryopreservation Patient Flow (10/2017)

PDF icon 08b. Ovarian Tissue Transport Logistics (10/2017)

PDF icon 08c. Removing an Ovary for Fertility Preservation with Pathology Examination (10/2017)

Section 9. Administrative Forms

PDF icon 09a. Administrative Forms and Their Uses (10/2017)

09b. Web Form:  Contact Information

File 09c. Form 2. Enrollment (10/2017)

Microsoft Office document icon 09e. Adverse Event Log

Microsoft Office document icon 09f. Serious Adverse Event Notification Form

IMPORTANT NOTE: The Adverse Event/Serious Adverse Event Logs are used for internal tracking of events at your own institution.

Section 10. Laboratory Procedures and Forms

PDF icon 10a. Laboratory Procedure: Sample Labeling (10/2017)

PDF icon 10b. Ovarian Tissue Log

PDF icon 10c. Ovarian Tissue Cryopreservation Procedure (10/2017)

PDF icon 10d. Laboratory Procedure: Sample Labels (10/2017)

Other Resources

Training Video: Dissection of a Whole Ovary in Preparation for Cryopreservation

Training Video: Dissection of a Partial Ovary in Preparation for Cryopreservation