The National Physicians Cooperative (NPC) is a nationwide network of centers dedicated to preserving the fertility of their patients.  Patients with cancer and other serious diseases whose progression or treatment is likely to impair fertility can receive access to the most up to date treatments and clinical research at NPC member sites. This page includes:

  • NPC mission and vision statements
  • NPC purpose and membership information
  • NPC subcommittees
  • How to become an NPC site (NPC Initiation Phase) and implement the ovarian tissue cryopreservation protocol (NPC Implementation Phase)
  • IRB templates for the ovarian tissue cryopreservation protocol
  • Billing resources: information and appeal letters
  • NPC-specific forms for patient enrollment to the ovarian tissue cryopreservation protocol. These can be found in "Section 9. Administrative Forms".

Mission Statement

To protect and preserve reproductive health through the continuum of care and across the lifespan of patients 

Vision Statement

The National Physicians Cooperative will investigate ways to mitigate the effects of any disease or treatment on ovarian and testicular function and develop physician-guided tools that will facilitate communication and translation between basic research and clinical practice


The NPC provides a framework for:

  • Nationwide referral of patients for fertility preservation procedures in their area
  • Multicenter clinical research studies in reproductive medicine
  • Dissemination of best practices and clinical breakthroughs
  • National testicular and ovarian tissue repositories to foster research to improve fertility preservation options for men, women, and children.

The NPC is led by Mary Ellen Pavone, MD, MSCI, at Northwestern University.

National Physicians Cooperative Membership

The NPC seeks member institutions that can cultivate strong working relationships between oncology (and other specialties who treat patients who may need fertility preservation interventions) and fertility preservation provider communities and that are committed to participation in NPC clinical research studies. 

National Physicians Cooperative Research Membership Requirements

  • Provide experimental procedures (such as ovarian tissue cryopreservation or testicular tissue cryopreservation) under IRB-approved protocols only
  • Participate in at least one study protocol that provides tissue to national ovarian or testicular tissue research repository
  • Follow NPC protocols and procedures
  • Share data with the NPC and abide by its guidelines for publication and commercialization

National Physicians Cooperative Clinical Membership Requirements

  • Provide high quality fertility preservation to diseased patients
  • Follow ASRM, ASCP, and AAP guidelines in advising patients
  • Offer ovarian and/or testicular tissue cryopreservation under IRB-approved protocols
  • Share annual metrics on cancer patients or fertility preservation procedures performed with the NPC

National Physicians Cooperative Membership Benefits

  • Access to a national referral network for patients seeking fertility preservation
  • Information on how to establish a multidisciplinary Fertility Preservation program
  • Training in the best practices, including technology updates and practice management
  • Templates and assistance for obtaining IRB approval for participation in multicenter NPC studies
  • Access to materials and tools as needed to support clinical studies
  • Compensation for the time and materials required to freeze tissues for the research pool
  • Invitations to annual meetings and special events
  • Information about the financial aspects of fertility preservation
  • Use of a Fertility Preservation Brochure tailored to your program