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Training the Globally Ready Scholar*
Site: University of Pennsylvania
Principal Investigator: Christos Coutifaris, MD, PhD
Rationale
In recent years, cancer diagnosis has changed, in many cases, from a death sentence to a disease with many survivors. Aggressive cancer treatments, although successful with respect to survival, may result in damage or loss of oocytes and impairment or loss of fertility. The purpose of the Oncofertility Consortium is to address the issue of fertility preservation in cancer patients with sufficiently trained physician-scientists who will implement the research and clinical agenda required to treat their patients with new and emerging technologies.
This multidisciplinary force of oncofertility specialists, specifically equipped to cope with the fertility concerns of patients with cancer, represents a new discipline in the field of Women’s Health. Long-term success will depend on how well the development of this global workforce is orchestrated, supported, and focused. It is the intent of this project to train and educate the first generation of oncofertility specialists in research related directly to the reproductive needs of the cancer patient and survivor. Education and training programs will facilitate the development of the oncofertility discipline that exists at the intersection of oncology, pediatrics, reproductive science and medicine, biomechanics, material science, mathematics, social science, bioethics, religion, policy research, reproductive health, law, and cognitive and learning science.
Specifically, this program will train and fund both NRSA eligible and non-NRSA eligible trainees through 2 different NIH grant mechanisms. Oncofertility training will merge entirely with the clinical and education objectives of the fellowship training program, Reproductive Endocrinology and Infertility (REI). Therefore, the likely source of oncofertility specialists will come directly from within the ranks of the REI subspecialty fellowships for advance training after completion of a residency in Obstetrics and Gynecology.
The objectives of this program are to:
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Expand the training of oncofertility specialists within REI programs across the nation through a rigorous educational, laboratory-based, and research curriculum.
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Seek federal funding for additional training dedicated to laboratory work and research related to oncofertility.
Indices of Scholarship
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Train fellows in cellular and molecular approaches to reproductive biology relevant to oncofertility and the responsible conduct of research
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Require the completion of additional didactic training and an online educational module
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Provide clinical exposure to adult and pediatric oncology patients who face the prospect of fertility loss or compromise
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Participate in an academic enrichment program consisting of seminars, lecture series, journal clubs, conferences, and retreats geared towards a comprehension of the interdisciplinary nature of oncofertility
Consortium Support and Impact
This project will draw on the biomedical and clinical research of the Oncofertility Consortium. Fellows will be trained in cryopreservation techniques and storage, follicle growth research in primates, the effects of cancer treatment on women’s reproductive capacities and the growth and maturation of human follicles, and tissue engineering applications. Each fellow will be expected to receive instruction in bio-psychosocial science, bioethics and religion, and reproductive health policy and law related to oncofertility. Online Resources will provide additional information to those being trained to ensure the optimal educational environment. Currently, there are 3 projects (see Fertility Measures After Cancer and Pilot Project Program) funded through the Consortium and being led by members of the first generation of oncofertility specialists, who use and provide feedback on the education and training program.
