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Fri May 4 2012

A publication in Human Reproduction highlights the ability to culture secondary follicles from cryopreserved macaque ovarian tissue. The authors Ting, Yeoman, Lawson, and Zelinski compared ovarian tissue after slow-freezing or vitrification and found that vitrification appeared to better maintain the morphology of stromal cells and secondary follicles, and the ability to form an antrum during 3D follicle culture.

Fri May 4 2012

In a recent publication in Tissue Engineering, Oncofertility Consortium® researchers examined the use of mouse embryonic fibroblasts (MEFs) in conjunction with a 3D-hydrogel-supported culture of ovarian follicles. Authors, Tagler, Tu, Smith, Anderson, Tingen, Woodruff, and Shea, found that coculture with the MEFs resulted in the survival and growth of primary and secondary follicles during the 14 days of culture.

Fri May 4 2012

In a publication in Tissue Engineering, Oncofertility Consortium® researchers identified new methods that may be utilized to increase the success of ovarian transplantation after cryopreservation. When ovarian tissue is transplanted back into a woman who preserved her fertility, revascularization of the tissue takes some time, during which many ovarian follicles are lost due to lack of oxygen and glucose.