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Both medical and non-medical factors have equally contributed to the emerging field of oncofertility. It is a microcosm of the medical, cultural and personal that shapes this field including, but not limited to: changes in cancer research, survival rates and treatment; cancer as a publicly acknowledged diagnosis; and a growing cultural acceptance of assisted reproductive technologies (ART). Taking a closer look at this history will help both patients and practitioners be more receptive to the overlapping issue that influence the field of oncofertility in the future.