PDF icon Effect of infertility treatment and pregnancy-related hormones on breast cell proliferation in vitro

Cooley A, Matthews L, Zelivianski S, Hardy A, and Jeruss J.S. Human Reproduction, Vol.0, No.0 pp. 1–7, 2011.

Synopsis

Breast cancer development involves a series of mutations in a heterogeneous group of proto-oncogenes/tumor suppressor genes that alter mammary cells to create a microenvironment permissive to tumorigenesis. Exposure to hormones during infertility treatment may have a mutagenic effect on normal mammary epithelial cells, high-risk breast lesions and early-stage breast cancers. Our goal was to understand the association between infertility treatment and normal and cancerous breast cell proliferation.